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未來學生 在校學生 新進學生 教職員工 訪客校友


郭代璜 教授兼副校長
簡介 計畫之所有研究或研究成果 發表論文



郭副校長 論文



  1. 1.Tzu-Yi Hung, Chiang-Ting Chou, Te-Kung Sun, Wei-Zhe Liang, Jin-Shiung Cheng, Yi-Chien Fang, Yih-Do Li, Pochuen Shieh, Chin-Man Ho, Chun-Chi Kuo, Jia-Rong Lin, Daih-Huang Kuo*, Chung-Ren Jan (2015). The Mechanism of Safrole-Induced [Ca2+]i Rises and Non-Ca2+-Triggered Cell Death in SCM1 Human Gastric Cancer Cells. Chinese Journal of Physiology, 58(5), 302-311. 本人為通訊作者
  3. 2.Yih-Do Li, Chiang-Ting Chou, Wei-Zhe Liang, Hui-Wen Tseng, Yi-Chien Fang, Tzu-Yi Hung, Hong-Tai Chang, Daih-Huang Kuo, Chun-Chi Kuo, Chin-Man Ho, Pochuen Shieh, Fu-An Chen, Chung-Ren Jan (2015). Effect of NPC-14686 (Fmoc-l-Homophenylalanine) on Ca2+ Homeostasis and Viability in OC2 Human Oral Cancer Cells. Chinese Journal of Physiology, 58(5), 285-293.
  5. 3.Jeng-Hsien Yeh, Te-Kung Sun, Chiang-Ting Chou, Wei-Chuan Chen, Jenn-Kuen Lee, Hsiao-Chun Yeh, Wei-Zhe Liang, Chun-Chi Kuo, Pochuen Shieh, Daih-Huang Kuo*, and Chung-Ren Jan (2015). Effect of Sertraline on Ca2+ Fluxes in Rabbit Corneal Epithelial Cells. Chinese Journal of Physiology, 58(2), 85-94. 本人為通訊作者.
  7. 4.郭代璜、蘇貞瑛,銀髮族幸福的照護,科學月刊509期:(2015);,42-47
  9. 5.Ko-Long Lin, Chiang-Ting Chou, Jin-Shiung Cheng, Hong-Tai Chang, Wei-Zhe Liang, Chun-Chi Kuo, I-Li Chen, Li-Ling Tseng, Pochuen Shieh, Ru-Fang Wu, Daih-Huang Kuo* and Chung-Ren Jan* (2014, Oct). Effect of Fluoxetine on [Ca2+]i and Cell Viability in OC2 Human Oral Cancer Cells. The Chinese Journal of Physiology, 57(5),256-264. 本人為通訊作者
  11. 6.Wei-Zhe Liang, Chiang-Ting Chou, Hong-Tai Chang, Jin-Shiung Cheng, Daih-Huang Kuo, Kuang-Chung Ko, Ni-Na Chiang, Ru-Fang Wui, Pochuen Shieh, Chung-Ren Jan* (2014, Sep). The mechanism of honokiol-induced intracellular Ca2+ rises and apoptosis in human glioblastoma cells . Chemico-Biological Interactions, 211,13-23.
  13. 7.Li-Min Liu, Shu-Fen Cheng, Po-Chuen Shieh, Jang-Chang Lee, Jih-Jung Chen, Chi-Tang Ho, Sheng-Chu Kuo, Daih-Huang Kuo*, Li-Jiau Huang*, Tzong-Der Way* (2014, Aug). The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats . Food and Chemical Toxicology, 70, 179–184. 本人為通訊作者
  15. 8.Min-Tsang Hsieh, Hao-Ping Chen, Chi-Cheng Lu, Jo-Hua Chiang, Tian-Shng Wu, Daih-Huang Kuo, Li-Jiau Huang, Sheng-Chu Kuo and Jai-Sing Yang (2014, Aug). The novel pterostilbene derivative ANK-199 induces autophagic cell death through regulating PI3 kinase class III/beclin 1/Atg‑related proteins in cisplatin‑resistant CAR human oral cancer cells. International Journal of Oncology, 452, 782-794.
  17. 9.Shu-Fen Peng*, Chao-Ying Lee*, Mann-Jen Hour, Shih-Chang Tsai, Daih-Huang Kuo, Fu-An Chen, Po-Chuen Shieh, Jai-Sing Yang (2014, Jul). Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway. International Journal of Oncology, 44, 238-246.
  19. 10.Hong-Tai Chang, Chiang-Ting Chou, Wei-Zhe Liang, Ti Lu, Daih-Huang Kuo, Pochuen Shieh, Chin-Man Ho, and Chung-Ren Jan. (2014, Apr). Effects of Thymol on Ca2+ Homeostasis and Apoptosis in MDCK Renal Tubular Cells. Chinese Journal of Physiology, 57(2), 90-98.
  21. 11.Chia-Cheng Yu, Chiang-Ting Chou, Te-Kung Sun, Wei-Zhe Liang,Jin-Shiung Cheng, Hong-Tai Chang, Jue-Long Wang, Hui-Wen Tseng,Chun-Chi Kuo, Fu-An Chen, Daih-Huang Kuo, Pochuen Shieh,Chung-Ren Jane* (2014, Apr). Effect of melamine on [Ca2+]i and viability in PC3 human prostate cancer cells . environmental toxicology and pharmacology , 38(3),800-806.
  23. 12.Yan-Jin Liu,Po-Chuen Shieh, Jang-Chang Lee, Fu-An Chen, Chih-Hung Lee, Sheng-Chu Kuo, Chi-Tang Ho, Daih-Huang Kuo* , Li-Jiau Huang* and Tzong-Der Way* (2014, Mar). Hypolipidemic activity of Taraxacum mongolicum is associated with the activation of AMP-activated protein kinase in human HepG2 cells. Food & Function, 1-35. 本人為通訊作者
  25. 13.Jau-Min Chien, Chiang-Ting Chou, Wei-Zhe Liang, Daih-Huang Kuo, Chun-Chi Kuo, Chin-Man Ho, Po-chuen Shieh, and Chung-Ren Jan (2014, Jan). The Mechanism of NPC-14686-Induced [Ca2+]i Rises and Non-Ca2+-Triggered Cell Death in MG63 Human Osteosarcoma Cells. Chinese Journal of Physiology, 57(3),158-166.
  27. 14.Kuang-Chi Lai*, Chi-Cheng Lu*, Yih-Jing Tang, Jo-Hua Chiang, Daih-Huang Kuo, Fu-An Chen, I-Li Chen, Jai-Sing Yang (2014, Jan). Allyl isothiocyanate inhibits cell metastasis through suppression of the MAPK pathways in epidermal growth factor‑stimulated HT29 human colorectal adenocarcinoma cells. Oncology Reports, 31, 189-196.
  29. 15.Chung-Pin Liu, Chiang-Ting Chou, Wei-Zhe Liang, Jin-Shiung Cheng, Hong-Tai Chang, Daih-Huang Kuo, Kuang-Chung Ko, Ni-Na Chiang, Ru-Fang Wu, Pochuen Shieh, and Chung-Ren Jan (2013, Dec). Pathways of [Ca2+]i rise evoked by angiotensin II in MDCK renal tubular cells. Journal of Receptors and Signal Transduction, 33(6), 380–386.
  31. 16.Hong-Tai Chang, I-Li Chen, Chiang-Ting Chou, Wei-Zhe Liang, Daih-Huang Kuo, Pochuen Shieh & Chung-Ren Jan. (2013, May). Effect of caffeic acid on Ca2+ homeostasis and apoptosis in SCM1 human gastric cancer cells. Arch Toxicol, 87, 2141–2150.
  33. 17.Chi-Ting Horng1, Ni-Na Chiang, I-Li Chen, Wei-Zhe Liang, I-Shu Chen, Daih-Huang Kuo, Po-Chuen Shieh,and Chung-Ren Jan (2013, Apr). Effect of clotrimazole on cytosolic Ca2+ rise and viability in HA59T human hepatoma cells. Journal of Receptors and Signal Transduction, 33(2), 89–95.
  35. 18.Daih-Huang Kuo, Ming-Chi Hung, Chao-Ming Hung, Li-Min Liu, Fu-An Chen, Po-Chuen Shieh, Chi-Tang Ho, Tzong-Der Way*. (2012, Oct). Body weight management effect of burdock (Arctium lappa L.) root is associated with the activation of AMP-activated protein kinase in human HepG2 cells. Food Chemistry, 134, 1320-1326.
  37. 19.Tsung-Hung Chang, I-Min Liu, Chi-Ting Horng, Feng-Chi Tsai, Daih-Huang Kuo, Po-Chuen Shieh, Shih-Chiang Lee, Jeng-Chuan Shiang, Fu-An Chen*. (2012, May). Beneficial effects of the burdock ferment liquid on diabetic disorders in STZ-induced diabetic rats. Life Science Journal-Acta Zhengzhou University Overseas Edition, 9(2), 823-831.
  39. 20.郭代璜、洪明吉,精油的神奇功效,科學月刊469期:(2012);14-19。
  41. 21.Ching-Shu Lai, You-Syuan Lai, Daih-Huang Kuo, Chih-Hsiung Wu, Chi-Tang Ho, Min-Hsiung Pan. (2011, Jul). Magnolol potently suppressed lipopolysaccharide-induced iNOS and COX-2 expression via downregulating MAPK and NF-kB signaling pathways. Journal of Functional Foods, 198-206.
  43. 22.Wei-Chuan Chen, Shu-Shong Hsu, Chiang-Ting Chou, Chun-Chi Kuo, Jong-Khing Huang, Yi-Chien Fang, Hong-Tai Chang, Jeng-Yu Tsai, Wei-Chuan Liao, Being-Whey Wangb, Pochuen Shieh, Daih-Huang Kuo, Chung-Ren Jan (2011, Apr). Effect of Diallyl Disulfide on Ca+2 Movement and Viability in PC3 Human Prostate Cancer Cells. Toxicol In Vitro, 25, 636-343.
  45. 23.Daih-Huang Kuo, Shin-Wen Tsai, and Min-Hsiung Pan (2011, Jan). Magnolol blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. Food Chemistry, 127, 135–140.
  47. 24.Tzy-Ming Lu, Daih-Huang Kuo, Horng-Huey Ko, Lean-Teik Ng. (2010, Aug). Synthesis and Structure-Activity Relationship Study of Deoxybenzoins on Relaxing Effects of Porcine Coronary Artery. Journal of Agricultural and Food Chemistry, 10027-10032.
  49. 25.Tzong-Der Way, Jang-Chang Lee, Daih-Huang Kuo, Ling-Ling Fan, Chi-Hung Huang, Hui-Yi Lin, Po-Chuen Shieh, Po-Tsun Kuo, Chien-Fu Liao, Hanshi Liu, Jung-Yie Kao*. (2010, Jun). Inhibition of Epidermal Growth Factor ReceptorSignaling by 2 Saussurea involucrata, a Rare Traditional Chinese Medicinal 3 Herb, in Humsn Hormone-Resistant Prostate Cancer PC-3 Cells. Journal of Agricultural and Food Chemistry, 58(6), 3356-3365.
  51. 26.Daih-Huang Kuo*, You-Syuan Lai, Chih-Yu Lo, An-Chin Cheng, Hou Wu, and Min-Hsiung Pan*. (2010, May). Inhibitory Effect of Magnolol on TPA-induced Skin Inflammation and Tumor Promotion in Mice. Journal of Agricultural and Food Chemistry, 58(9), 5777-5783.
  53. 27.Chun-Chi Kuo, Daih-Huang Kuo, Chun-Jen Huang, Yi-Chien Fang, Pochuen Shieh, Fu-An Chen, Chen-Fu Shaw, Chung-Ren Jan*. (2010, Apr). Nonylphenol-Induced Apoptotic Pathways in SCM1 Human Gastric Cancer Cells. Drug Development Research, 71(2), 139-148.
  55. 28.Jeng-Hsien Yeh, Jenn-Kuen Lee, Jyh-Seng Wang, Mei-Yin Yeh, Yu-Lin Yang, Jau-Shyang Huang, Wen-Teng Chang, Daih-Huang Kuo, Po-chuen Shieh, Fu-An Chen, Chun-Chi Kuo, Chung-Ren Jan*. (2010, Apr). Effect of Capsaicin on Ca2+ Fluxes in Madin-Darby Canine Renal Tubular Cells.. Drug Development Research , 71(2), 112-119.
  57. 29.Daih-Huang Kuo*, Li-Min Liu, Hsin-Wei Chen, Fu-An Chen, Chung-Ren Jan. (2010, Feb). Econazole-Induced Ca2+ Fluxes and Apoptosis in Human Oral Cancer Cells. Drug Development Research , 71, 240-248.
  59. 30.Chi-Tin Horn, I-Min Liu, Daih-Huang Kuo, Ya-Wen Tsai, Po-Chuen Shieh*.(2010) Comparison of Xanthine Oxidase-Inhibiting and Free Radical-Scavenging Activities Between Plant Adaptogens of Eleutherococcus Senticosus and Rhodiola Rosea. Drug Development Research. 71 (4): 249-252.
  61. 31.Po-Chuen Shieh*, Yi-Own Chen, Daih-Huang Kuo, Fu-An Chen, Mei-Ling Tsai, Ing-Shing Chang, Hou Wu, Shengmin Sang, Chi-Tang Ho. Min-Hsiung Pan*. (2010, Feb). Induction of Apoptosis by [8]-Shogaol via Reactive Oxygen Species Generation, Glutathione Depletion, and Caspase Activation in Human Leukemia Cells. Journal of Agricultural and Food Chemistry , 58(6), 3847-3854.
  63. 32.Chieh-Wen Cheng, Po-Chuen Shieh, Ying-Chao Lin, Yi-Jen Chen, Yu-Huei Lin, Daih-Huang Kuo, Jah-Yao Liu, Jung-Yie Kao, Ming-Ching Kao, Tzong-Der Way. (2010, Jan). Indoleamine 2,3-Dioxygenase, an Immunomodulatory Protein, Is Suppressed by (-)-Epigallocatechin-3-Gallate via Blocking of Garmma-Interferon-Induced JAK-PKC-Deslta-STAT1 Signaling in Human Oral Cancer Cells. Journal of Agricultural and Food Chemistry, 58(2), 887-894.
  65. 33.Chih Chuan Pan, Daih-Huang Kuo, Pochuen Shieh, Fu-An Chen, Chun-Chi Kuo, Chung-Ren Jan*. (2010, Jan). Effect of the Antidepressant Paroxetine on Ca2+ Movement in PC3 Human Prostate Cancer Cells. . Drug Development Research , 71(2), 120-126. (SCI)
  68. 34.Daih-Huang Kuo*, Wen-Hsimg Kang, Po-Chuen Shieh, Fu-An Chen, Ching-Dong Chang, Mei-Ling Tsai, An-Chin Cheng, Chi-Tang Ho, Min-Hsiung Pan. (2010, Jan). Protective Effect of Pracparatum Mungo Extract on Carbon Tetrachloride-induced Hepatotoxicity in Rats. Food Chemistry, 123 (4), 1007-1012.
  70. 35.Jia-Ni Lin, Victor C. Lin, Kun-Ming Rau, Po-Chuen Shieh, Daih-Huang Kuo, Jia-Ching Shieh, Wei-Jen Chen, Shih-Chang Tsai, Tzong-Der Way*. (2010, Jan). Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation. Journal of Agricultural and Food Chemistry , 58 (3), 1584-1592.
  72. 36.Po-Chuen Shieh, Govindasamy Agoramoorthy, Daih-Huang Kuo*. Evaluation of Antioxidant Polyphenols in Taiwan's Medicinal Plants. Asian Journal of Chemistry. 2009; 21(7):5556-5562. SCI ;IF:0.238【通訊作者】
  74. 37.Daih-Huang Kuo, Ching-Hua Yeh, Po-Chuen Shieh, Kai-Chun Cheng, Fu-An Chen, Juei-Tang Cheng*. Effect of ShanZha, a Chinese Herbal Product, on Obesity and Dyslipidemia in Hamsters Receiving High-Fat Diet. Journal of Ethnopharmacology. 2009124(3):544-550. SCIIF: 2.986【第一作者】


  1. 38.Chun-Jen Huang, Daih-Huang Kuo, Kai-Hsien Chang, Pochuen Shieh, Fu-An Chen, Yi-Chien Fang, Chun-Chi Kuo, Chung-Ren Jan. Effect of the Antidepressant Sertraline on Ca2+ Fluxes in Madin-Darby Canine Renal Tubular Cells. Journal of Receptors and Signal Transduction. 2009; 29(6): 342-348.SCIIF:1.992
  3. 39.Yi-Chien Fang, Daih-Huang Kuo, Pochuen Shieh, Fu-An Chen, Chun-Chi Kuo, Chung-Ren Jan. Effect of M-3M3FBS on Ca2+ Movement in Madin-Darby Canine Renal Tubular Cells. Human and Experimental Toxicology. 200928(10):655-663. SCI;IF:1.667
  5. 40.Tzong-Der Way, Hui-Yi Lin, Daih-Huang Kuo, Shang-Jie Tsai, Jia-Ching Shieh, Jia-Ching Wu, Maw-Rong Lee, Jen-Kun Lin*. Pu-erh Tea Attenuates Hyperlipogenesis and Induces Hepatoma Cells Growth Arrest through Activating AMP-Activated
  6. Protein Kinase (AMPK) in Human HepG2 Cells. Journal of Agricultural and Food Chemistry. 2009 ; 57(12):5257-64. SCI ;IF:3.051
  8. 41.Chi-Ting Horng, Te-Sheng Wen, Jeng-Chuan Shiang, Ming-Liang Tsai, Daih-Huang Kuo*. A Study of Cardiovascular Effects of Rhodiola Sacra. Journal of Aviaiont Medicine and Science. 2008; 22(1): 5-12. TSSCI 【通訊作者】
  10. 42.Cheng-Dean Shih*, Daih-Huang Kuo, Chi-Wen Huang, Yu-Hua Ga, Fu-An Chen. Autonomic Nervous System Mediates the Cardiovascular Effects of Rhodiola Sacra Radix in Rats. Journal of Ethnopharmacology. 2008; 119(2): 284-90. SCIIF: 2.986
  13. 43.Govindasamy Agoramoorthy, Fu-An Chen, Venugopalan Venkatesalu, Daih-Huang Kuo, Po-Chuen Shieh*. Evaluation of Antioxidant Polyphenols from Selected Mangrove Plants of India. Asian Journal of Chemistry. 200820(2), 1311-1322 . SCI ;IF:0.238
  15. 44.Daih-Huang Kuo, Chi-Ting Horng, Fu-An Chen, Jih-Jung Chen, Zhi-Wei Wang, Po-Chuen Shieh. Study of Synthesis and 1H NMR Chemical Shift for Diazoketones. Tajen Journal. 2007; 30: 1-11. 【第一作者】
  17. 45.Daih-Huang Kuo, Pochuen Shieh, Bin-Hong Yang, Chi-Ting Horng, Fu-An Chen*. Vasorelaxation Effect of Cymbopogon Citratus in Isolated Porcine Coronary Artery.Taiwan Pharmaceutical Journal. 200759 (2) : 85-96. TSSCI 【第一作者】
  19. 46.Po-Chuen Shieh, Su-Shiang Cheng, Daih-Huang Kuo, Wen-Cheng Fu, Mei-Chich Hsu, Fu-An Chen*. Simple and Rapid Liquid Chromatographic Method for Determination of Histidine HCl in Pharmaceutical Preparations. Taiwan Pharmaceutical Journal. 200759 (3), 141-148 . TSSCI
  21. 47.Fu-An Chen*, An-Bang Wu, Pochuen Shieh, Daih-Huang Kuo, Chi-Ying Hsieh*. Evaluation of the Antioxidant Activity of Ruellia Tuberose. Food Chemistry. 200694: 14-18. SCI ;IF:3.606
  23. 48.Tai-Chi Wang*, I-Li Chen, Chai-Ming Lu, Daih-Huang Kuo, Chang-Hui Liao. Synthesis, and Cytotoxic and Antiplatelet Activities of Oxime- and Methyloxime-Containing Flavone, Isoflavone, Xanthone Derivatives. Chemistry & Biodiversity. 2005; 2(2): 253-263. SCI ;IF:3.046
  25. 49.Yeh-Long Chen*, Chih-Ming Lu, Shoiw-Ju Lee, Daih-Huang Kuo, I-Li Chen, Tai-Chi Wang, Cherng-Chyi Tzeng. Synthesis, Antiproliferative, and Vasorelaxing Evaluations of Coumarin α-Methylene-γ-Butyrolactones. Bioorganic & Medicinal Chemistry. 2005 13(20): 5710-5716. SCI ;IF:3.046
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